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Type II secretion system
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Type II secretion system : ウィキペディア英語版
Type II secretion system
The type 2 secretion system (often referred to as the type II secretion system or the T2SS) is protein secretion machinery found in various species of gram negative bacteria, including various human pathogens such as ''Pseudomonas aeruginosa'' and ''Vibrio cholerae''. The type II secretion system is one of six protein secretory systems that are commonly found in gram negative bacteria along with the type I secretion system, the type III secretion system, The type IV secretion system, the chaperone/usher pathway, the autotransporter pathway/type V secretion system and the type VI secretion system (some bacteria also utilize the type VII secretion system). Like these other systems, the type II secretion system enables the transport of cytoplasmic proteins across the lipid bilayers that make up the cell membranes in gram negative bacteria.
==Overview==

The type II secretion system is a membrane bound protein complex found in gram negative bacteria that is used to secrete proteins found in the cytoplasm of the bacteria into the extracellular milieu outside of the cell. The type II secretion system is just one of many secretory systems found in Gram negative bacteria and is used to secrete a variety of different proteins, including bacterial toxins and degradative enzymes such as proteases and lipases. These secreted proteins are generally associated with the breakdown of host tissues and therefore are often important in causing the symptoms associated with certain bacterial infections. Each bacterial cell will contain a number of type II secretion systems and these are found embedded in the inner and outer membranes of the cell.
Along with other secretory systems such as the chaperone/usher pathway and the type IV secretion system, secretion via the type II secretion system is a two-step process. The first step involves the Sec and Tat secretory pathways which are responsible for transporting proteins across the inner membrane into the periplasm. For instance the Sec pathway is used to transport structural components of the type II secretion system into the periplasm where they can then assemble, while both the Sec and Tat pathways are used to transport secretory proteins into the periplasm. Once these secretory proteins are in the periplasm the second step can then take place and they are secreted out of the cell through the type II secretion system.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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